Structure of PDB 4h0n Chain A Binding Site BS02

Receptor Information

>4h0n Chain A (length=331) Species: 7108 (Spodoptera frugiperda)

SHKILELYSGIGGMHCAWKESGLDGEIVAAVDINTVANSVYKHNFPETNL
LNRNIQQLTPQVIKKWNVDTILMSPPCQPFTRNGKYLDDNDPRTNSFLYL
IGILDQLDNVDYILMENVKGFENSTVRNLFIDKLKECNFIYQEFLLCPST
VGVPNSRLRYYCTARRNNLTWPFKRRDEIITRLPKDFGVPHSLESIIEED
VDEKFLVPEKMLRCAKVFDICYKTSKRSCCFTKAYTHYADGTGSIFTDKP
REVVQKCYAAAAQNEIGGEKFVELFKELKLRYFTPKEVLMIMCFPKSYNL
PTNISMKQCYRLLGNSVNVKVISELLKILFE

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4h0n Chain A Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4h0n Functional and structural characterization of DNMT2 from Spodoptera frugiperda.
• Resolution: 2.712 Å
• Binding residue (original residue number in PDB): G103 D106
• Binding residue (residue number reindexed from 1): G102 D105
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): C78 E117 R158 R160
• Catalytic site (residue number reindexed from 1): C77 E116 R157 R159
• Enzyme Commision number: 2.1.1.204: tRNA (cytosine(38)-C(5))-methyltransferase.
  2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0003886 DNA (cytosine-5-)-methyltransferase activity
• GO:0008168 methyltransferase activity

Biological Process

• GO:0008033 tRNA processing
• GO:0032259 methylation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:4h0n, PDBe:4h0n, PDBj:4h0n
• PDBsum: 4h0n
• PubMed: 23103599
• UniProt: A0A2H1VE33|TRDMT_SPOFR tRNA (cytosine(38)-C(5))-methyltransferase (Gene Name=TRDMT1)