Structure of PDB 4gyi Chain A Binding Site BS02

Receptor Information

>4gyi Chain A (length=339) Species: 759272 (Thermochaetoides thermophila DSM 1495)

KLDTRAMRHLTAEDWRVLTAVEMGSKNHEIVPTPLIEKIARLRGGSSGVH
KSIATLAKAGLIARMKEAKYDGYRLTYGGLDYLALHTHAARKDVYSVGSR
IGVGKESDIMIVADEKGKQKVLKIHRLGRISFRTVKRDYLRNRSTGSWMY
LSRLAAIKEFAFMKALYEEGFPVPEPIAQSRHTIVMSLVDALPMRQVSSV
PDPASLYADLIALILRLAKHGLIHGDFNEFNILIREEKDAEDPSSITLTP
IIIDFPQMVSMDHPNAEMYFDRDVQCIKRFFERRFHFVSTTPGPFYKDAK
KTVGKDGAKRLDAALEASGFTKKMAKDLEAAIREQQESR

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4gyi Chain A Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4gyi ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): N234 X257
• Binding residue (residue number reindexed from 1): N231 X254
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0005524 ATP binding
• GO:0044024 histone H2AS1 kinase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006338 chromatin remodeling
• GO:0006468 protein phosphorylation
• GO:0016310 phosphorylation
• GO:0030490 maturation of SSU-rRNA

Cellular Component

• GO:0005634 nucleus
• GO:0005829 cytosol
• GO:0030688 preribosome, small subunit precursor

External links

• PDB: RCSB:4gyi, PDBe:4gyi, PDBj:4gyi
• PDBsum: 4gyi
• PubMed: 23104056
• UniProt: G0S5R3