Structure of PDB 4glx Chain A Binding Site BS02

Receptor Information
>4glx Chain A (length=573) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPEL
ITPDSPTQRPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQDRTWCCE
LKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGEN
IPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPR
ITAKRPLTFFCYGVGVLEGGELPDTHLGRLLQFKKWGLPVSDRVTLCESA
EEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQLGFVARAPRWAVAF
KFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADE
IERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTREVVFPTHCPVCGS
DVERVEGEAVARCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLV
EKEYVHTPADLFKLTAGKLTGLERMGPKSAQNVVNALEKAKETTFARFLY
ALGIREVGEATAAGLAAYFGTLEALEAASIEELQKVPDVGIVVASHVHNF
FAEESNRNVISELLAEGVHWPAP
Ligand information
Receptor-Ligand Complex Structure
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PDB4glx Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		G118 L119 A120 T135 R136 G137 R208 D452 G453 G455 K457 I458 R487
Binding residue
(residue number reindexed from 1)		G105 L106 A107 T122 R123 G124 R195 D439 G440 G442 K444 I445 R474
Enzymatic activity
Catalytic site (original residue number in PDB) Y225 T427
Catalytic site (residue number reindexed from 1) Y212 T414
Enzyme Commision number 6.5.1.2: DNA ligase (NAD(+)).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003911 DNA ligase (NAD+) activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4glx, PDBe:4glx, PDBj:4glx
PDBsum4glx
PubMed23006603
UniProtP15042|DNLJ_ECOLI DNA ligase (Gene Name=ligA)

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