Structure of PDB 4gjz Chain A Binding Site BS02

Receptor Information
>4gjz Chain A (length=228) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STVPRLHRPSLQHFREQFLVPGRPVILKGVADHWPCMQKWSLEYIQEIAG
CRTVPVEVGWSQTLMTVNEFISKYIVNEPRDVGYLAQHQLFDQIPELKQD
ISIPDYCSLGDGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVMGRKYI
RLYSPQESGALYPHDTHLLHNTSQVDVENPDLEKFPKFAKAPFLSCILSP
GEILFIPVKYWHYVRALDLSFSVSFWWS
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain4gjz Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gjz Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function.
Resolution1.0481 Å
Binding residue
(original residue number in PDB)		Y272 W310 S318 H321 N327 K336 H400 V402 W414
Binding residue
(residue number reindexed from 1)		Y84 W122 S130 H133 N139 K148 H212 V214 W226
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.73: [protein]-arginine 3-hydroxylase.
3.4.-.-
External links
PDB RCSB:4gjz, PDBe:4gjz, PDBj:4gjz
PDBsum4gjz
PubMed22851697
UniProtQ8N371|KDM8_HUMAN Bifunctional peptidase and arginyl-hydroxylase JMJD5 (Gene Name=KDM8)

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