Structure of PDB 4g0u Chain A Binding Site BS02

Receptor Information

>4g0u Chain A (length=655) Species: 9606 (Homo sapiens)

PKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRG
KILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMI
MTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITERHRILFRYAGPE
DDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLKHLTYNDFINKELILFS
NSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY
HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIF
TMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIG
TGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQY
AVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDY
KEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMG
CLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE
KIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEGPDFNYILNMSL
WSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVES
QERED

Ligand information

>4g0u Chain D (length=12)

tgcagctcggct

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4g0u On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): G478 D479 S480 R503 Q778
• Binding residue (residue number reindexed from 1): G24 D25 S26 R49 Q255

Enzymatic activity

• Enzyme Commision number: 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
• GO:0005524 ATP binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006265 DNA topological change

External links

• PDB: RCSB:4g0u, PDBe:4g0u, PDBj:4g0u
• PDBsum: 4g0u
• PubMed: 24038465
• UniProt: Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta (Gene Name=TOP2B)