Structure of PDB 4fxd Chain A Binding Site BS02

Receptor Information
>4fxd Chain A (length=848) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFQMFWLDYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRELFFLPREG
KTPTDIHEEIIPLLMDKYGLDNIRAKPQKMKYSFELPDIPSESDYLKVLL
PYQTPKSSRDTIPSDLSSDTFYHVFGGNSNIFESFVIQNRIMGPCWLDIK
GADFNSIRNASHCAVEVSVDKPQNITPTTTKTMPNLRCLSLSIQTLMNPK
ENKQEIVSITLSAYRNISLDSPIPENIKPDDLCTLVRPPQSTSFPLGLAA
LAKQKLPGRVRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQNVYLDVLAH
RMHDLNIPTFSSIGRRLRRTWPEKFGRGNSNMNHFFISDICSGRLICDIA
NEMGQSLTPKCQSWDLSEMYQVTCEKEHKPLDIDYQNPQYQNDVNSMTMA
LQENITNCMISAEVSYRIQLLTLTKQLTNLAGNAWAQTLGGTRAGRNEYI
LLHEFSRNGFIVPDKVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTT
VDRNKEDIDELPSVPPSEVDQGVLPRLLANLVDRRREVKKVMKTETDPHK
RVQCDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTR
QLAESMNLLVVYGDTDSVMIDTGCDNYADAIKIGLGFKRLVNERYRLLEI
DIDNVFKKLLLHAKKKYAALTVNLDKNGNGTTVLEVKGLDMKRREFCPLS
RDVSIHVLNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINMK
LSKDPKAYPGGKNMPAVQVALRMRKAGRVVKAGSVITFVITKLSVAERAH
ALNEVMIKSNNLIPDPQYYLEKQIFAPVERLLERIDSFNVVRLSEALG
Ligand information
Receptor-Ligand Complex Structure
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PDB4fxd Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K1047 K1069 G1070 R1075 R1076 M1131 K1132 S1134 K1135 Y1140
Binding residue
(residue number reindexed from 1)		K665 K687 G688 R693 R694 M749 K750 S752 K753 Y758
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:1902975 mitotic DNA replication initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:4fxd, PDBe:4fxd, PDBj:4fxd
PDBsum4fxd
PubMed23599895
UniProtP13382|DPOLA_YEAST DNA polymerase alpha catalytic subunit A (Gene Name=POL1)

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