Structure of PDB 4fvk Chain A Binding Site BS02

Receptor Information

>4fvk Chain A (length=367) Species: 1129345 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/153/2009(H17N10)))

FYWRAKSQMCEVKGWVPTHRGFPWGPELPGDLILSRRAYVSCDLTSCFKF
FIAYGLSANQHLLNTSMEWEESLYKTPIGSASTLSTSEMILPGRSSSACF
DGLKWTVLVANGRDRNSFIMIKYGEEVTDTFSASRGGPLRLPNSECICIE
GSCFVIVSDGPNVNQSVHRIYELQNGTVQRWKQLNTTGINFEYSTCYTIN
NLIKCTGTNLWNDAKRPLLRFTKELNYQIVEPCNGAPTDFPRGGLTTPSC
KMAQEKGEGGIQGFILDEKPAWTSKTKAESSQNGFVLEQIPNGIESEGTV
SLSYELFSNKRTGRSGFFQPKGDLISGCQRICFWLEIEDQTVGLGMIQEL
STFCGINSPVQNINWDS

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 4fvk Chain A Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4fvk Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus
• Resolution: 2.198 Å
• Binding residue (original residue number in PDB): E386 T388
• Binding residue (residue number reindexed from 1): E297 T299
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): W154 Y277 T292 Q371 R406
• Catalytic site (residue number reindexed from 1): W69 Y193 T208 Q282 R314
• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:4fvk, PDBe:4fvk, PDBj:4fvk
• PDBsum: 4fvk
• PubMed: 23012237
• UniProt: H6QM75