Structure of PDB 4fte Chain A Binding Site BS02

Receptor Information
>4fte Chain A (length=328) Species: 12287 (Flock House virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRLSQPGLAFLKCAFAPPNFNTDPGKGIPDRFEGKVVSRKDVLNQSISFT
AGQDTFILIAPTPGVAYWSASVPAGTFPTSATTFNPVNYPGFTSMFGTTS
TSRSDQVSSFRYASMNVGIYPTSNLMQFAGSITVWKCPVKLSTVQFPVAT
DPATSSLVHTLVGLDGVLAVGPDNFSESFIKGVFSQSACNEPDFEFNDIL
EGIQTLPPANVSLGSTGQPFTMDSGAEATSGVVGWGNMDTIVIRVSAPEG
AVNSAILKAWSCIEYRPNPNAMLYQFGHDSPPLDEVALQEYRTVARSLPV
AVIAAQNASMWERVKSIIKSSLAAASNI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4fte Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4fte Structural study of virus assembly intermediates reveals maturation event sequence and a staging position for externalized lytic peptides
Resolution3.5 Å
Binding residue
(original residue number in PDB)		D249 E251
Binding residue
(residue number reindexed from 1)		D193 E195
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.23.44: nodavirus endopeptidase.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0046718 symbiont entry into host cell
GO:0140267 symbiont entry into host cell via permeabilization of host membrane
Cellular Component
GO:0039617 T=3 icosahedral viral capsid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fte, PDBe:4fte, PDBj:4fte
PDBsum4fte
PubMed
UniProtP12870|CAPSD_FHV Capsid protein alpha (Gene Name=alpha)

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