Structure of PDB 4fs1 Chain A Binding Site BS02

Receptor Information
>4fs1 Chain A (length=383) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQYDVMT
PMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB4fs1 Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Q59 K60 Y61 V64 L99 P299 Q300 S301 S303 E304 E305 S307 F308 K309 R331
Binding residue
(residue number reindexed from 1)		Q34 K35 Y36 V39 L74 P274 Q275 S276 S278 E279 E280 S282 F283 K284 R306
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4fs1, PDBe:4fs1, PDBj:4fs1
PDBsum4fs1
PubMed22910910
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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