Structure of PDB 4fm9 Chain A Binding Site BS02

Receptor Information
>4fm9 Chain A (length=727) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYG
VFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLR
YGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSK
NKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMK
RHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPE
DYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFT
CFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLN
LLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDD
NQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDG
EEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWT
QTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAER
VGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGL
RKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGY
DSDPVKAWKETFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSP
SDLWKEDLATFIEELEAVEAKEKQDEQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4fm9 The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage.
Resolution2.901 Å
Binding residue
(original residue number in PDB)		K489 L491 N492 H548 L552 F653 R661 K662 I856 G857 T858 G859 W860 S861 K990 S994 T996 N998 S999
Binding residue
(residue number reindexed from 1)		K57 L59 N60 H116 L120 F221 R229 K230 I424 G425 T426 G427 W428 S429 K558 S562 T564 N566 S567
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4fm9, PDBe:4fm9, PDBj:4fm9
PDBsum4fm9
PubMed22841979
UniProtP11388|TOP2A_HUMAN DNA topoisomerase 2-alpha (Gene Name=TOP2A)

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