Structure of PDB 4fm1 Chain A Binding Site BS02

Receptor Information
>4fm1 Chain A (length=755) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGMIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAI
DEVKKITAERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIRE
KIREHPAVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHE
GEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVI
REKDPDVIITYNGDNFAFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSL
AVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEA
WETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSS
TGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEKEPEKGLWEGIV
SLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPS
LLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAK
ARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAK
HEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGK
IVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSK
YEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYI
VLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRK
EDLKY
Ligand information
Receptor-Ligand Complex Structure
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PDB4fm1 Molecular Recognition of Canonical and Deaminated Bases by P. abyssi Family B DNA Polymerase.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Y7 P36 P90 Q91 V93 P94 R97 Y112 D113 I114 P115 F116 R119 R243 G245 K593 A675 I676 I710 S711 Y731
Binding residue
(residue number reindexed from 1)		Y9 P38 P92 Q93 V95 P96 R99 Y114 D115 I116 P117 F118 R121 R245 G247 K591 A673 I674 I708 S709 Y729
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4fm1, PDBe:4fm1, PDBj:4fm1
PDBsum4fm1
PubMed22902479
UniProtP0CL77|DPOL_PYRAB DNA polymerase 1 (Gene Name=polI)

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