Structure of PDB 4flz Chain A Binding Site BS02

Receptor Information
>4flz Chain A (length=754) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGMIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAI
DEVKKITAERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIRE
KIREHPAVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHE
GEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVI
REKDPDVIITYNGDNFAFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSL
AVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEA
WETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSS
TGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYKEPEKGLWEGIVS
LDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSL
LGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKA
RWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKH
EEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKI
VTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKY
EIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIV
LRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKE
DLKY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4flz Molecular Recognition of Canonical and Deaminated Bases by P. abyssi Family B DNA Polymerase.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		Y7 I8 T9 P36 Y37 P90 Q91 R97 E111 Y112 D113 I114 P115 F116 R119 K240 Q242 R243 G245 K253 Y500 A675 I676 I710 S711 Y731
Binding residue
(residue number reindexed from 1)		Y9 I10 T11 P38 Y39 P92 Q93 R99 E113 Y114 D115 I116 P117 F118 R121 K242 Q244 R245 G247 K255 Y497 A672 I673 I707 S708 Y728
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4flz, PDBe:4flz, PDBj:4flz
PDBsum4flz
PubMed22902479
UniProtP0CL77|DPOL_PYRAB DNA polymerase 1 (Gene Name=polI)

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