Structure of PDB 4flw Chain A Binding Site BS02

Receptor Information
>4flw Chain A (length=758) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HAGMIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSA
IDEVKKITAERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIR
EKIREHPAVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYH
EGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKV
IREKDPDVIITYNGDNFAFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDS
LAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAE
AWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRS
STGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGVKEPEKGLWE
GIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGF
IPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYG
YAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIP
GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE
EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEK
LSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVI
GYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVERILRAFG
YRKEDLKY
Ligand information
Receptor-Ligand Complex Structure
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PDB4flw Molecular Recognition of Canonical and Deaminated Bases by P. abyssi Family B DNA Polymerase.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		Y7 P36 Y37 P90 Q91 V93 P94 R97 E111 Y112 D113 I114 P115 F116 R119 R243 G245 D246 K502 K593 W615 A675 I676 I710 S711 Y731 R743
Binding residue
(residue number reindexed from 1)		Y10 P39 Y40 P93 Q94 V96 P97 R100 E114 Y115 D116 I117 P118 F119 R122 R246 G248 D249 K503 K594 W616 A676 I677 I711 S712 Y732 R744
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4flw, PDBe:4flw, PDBj:4flw
PDBsum4flw
PubMed22902479
UniProtP0CL77|DPOL_PYRAB DNA polymerase 1 (Gene Name=polI)

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