Structure of PDB 4fiy Chain A Binding Site BS02

Receptor Information
>4fiy Chain A (length=628) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSELAASLLSRVILPRPGEPLDVRKLYLEESTTNARRAHAPTRTSLQIGA
ESEVSFATYFNAFPASYWRRWTTCKSVVLRVQVTGAGRVDVYRTKATGAR
IFVEGHDFTGTEDQPAAVETEVVLQPFEDGGWVWFDITTDTAVTLHSGGW
YATSPAPGTANIAVGIPTFNRPADCVNALRELTADPLVDQVIGAVIVPDQ
GERKVRDHPDFPAAAARLGSRLSIHDQPNLGGSGGYSRVMYEALKNTDCQ
QILFMDDDIRLEPDSILRVLAMHRFAKAPMLVGGQMLNLQEPSHLHIMGE
VVDRSIFMWTAAPHAEYDHDFAEYPLNDNNSRSKLLHRRIDVDYNGWWTC
MIPRQVAEELGQPLPLFIKWDDADYGLRAAEHGYPTVTLPGAAIWHMAWS
DKDDAIDWQAYFHLRNRLVVAAMHWDGPKAQVIGLVRSHLKATLKHLACL
EYSTVAIQNKAIDDFLAGPEHIFSILESALPQVHRIRKSYPDAVVLPAAS
ELPPPLHKNKAMKPPVNPLVIGYRLARGIMHNLTAANPQHHRRPEFNVPT
QDARWFLLCTVDGATVTTADGCGVVYRQRDRAKMFALLWQSLRRQRQLLK
RFEEMRRIYRDALPTLSSKQKWETALLP
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4fiy Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4fiy Tetrameric Structure of the GlfT2 Galactofuranosyltransferase Reveals a Scaffold for the Assembly of Mycobacterial Arabinogalactan.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D256 D258 H396
Binding residue
(residue number reindexed from 1)		D256 D258 H396
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.288: galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho- decaprenol beta-1,5/1,6-galactofuranosyltransferase.
Gene Ontology
Molecular Function
GO:0008921 lipopolysaccharide-1,6-galactosyltransferase activity
GO:0016740 transferase activity
GO:0016757 glycosyltransferase activity
GO:0035250 UDP-galactosyltransferase activity
GO:0035496 lipopolysaccharide-1,5-galactosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0044038 cell wall macromolecule biosynthetic process
GO:0045227 capsule polysaccharide biosynthetic process
GO:0052573 UDP-D-galactose metabolic process
GO:0070592 cell wall polysaccharide biosynthetic process
GO:0071555 cell wall organization
GO:0071769 mycolate cell wall layer assembly
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:4fiy, PDBe:4fiy, PDBj:4fiy
PDBsum4fiy
PubMed22707726
UniProtO53585|GLFT2_MYCTU Galactofuranosyltransferase GlfT2 (Gene Name=glfT2)

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