Structure of PDB 4fgf Chain A Binding Site BS02

Receptor Information
>4fgf Chain A (length=124) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVC
ANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALK
RTGQYKLGSKTGPGQKAILFLPMS
Ligand information
Ligand IDBME
InChIInChI=1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2
InChIKeyDGVVWUTYPXICAM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CS)O
ACDLabs 10.04
CACTVS 3.341		OCCS
FormulaC2 H6 O S
NameBETA-MERCAPTOETHANOL
ChEMBLCHEMBL254951
DrugBankDB03345
ZINCZINC000008216595
PDB chain4fgf Chain A Residue 149 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4fgf Refinement of the structure of human basic fibroblast growth factor at 1.6 A resolution and analysis of presumed heparin binding sites by selenate substitution.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		E58 S64 V88 T89 C92 F93
Binding residue
(residue number reindexed from 1)		E39 S45 V69 T70 C73 F74
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008083 growth factor activity

View graph for
Molecular Function
External links
PDB RCSB:4fgf, PDBe:4fgf, PDBj:4fgf
PDBsum4fgf
PubMed7691311
UniProtP09038|FGF2_HUMAN Fibroblast growth factor 2 (Gene Name=FGF2)

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