Structure of PDB 4fbe Chain A Binding Site BS02

Receptor Information

>4fbe Chain A (length=303) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ELVDIPKISYNPSELSEPRFLEYSNLSDKLHLREAIDKILIPRVVGTTNH
SIVREYIVQSLRDLDWDVEVNSFHDHAPIKGKLHFHNIIATLNPNAERYL
VLSAHYDSKYMPGVEFLGATDSAVPAAMLLNLAQVLQEQLKPLKKSKLSL
MLLFFDGEEAFEEWGPKDSIYGARHLAKKWHHEGKLDRIDMLVLLDLLGA
PDPAFYSFFENTESWYMRIQSVETRLAKLQLLERYFQSQAMRSSFIEDDH
IPFLRRNVPILHLIPVPFPSVWHTPDDNASVIDYATTDNLALIIRLFALE
YLL

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4fbe Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4fbe Crystal Structures of Glutaminyl Cyclases (QCs) from Drosophila melanogaster Reveal Active Site Conservation between Insect and Mammalian QCs.
Resolution	1.88 Å
Binding residue (original residue number in PDB)	D153 E191 H318
Binding residue (residue number reindexed from 1)	D121 E159 H273
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.3.2.5: glutaminyl-peptide cyclotransferase.

Gene Ontology

	Molecular Function
GO:0008270	zinc ion binding
GO:0016603	glutaminyl-peptide cyclotransferase activity
GO:0016746	acyltransferase activity
GO:0046872	metal ion binding

	Cellular Component
GO:0005576	extracellular region
GO:0005739	mitochondrion

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4fbe, PDBe:4fbe, PDBj:4fbe
PDBsum	4fbe
PubMed	22897232
UniProt	Q86PD7\|QPCT2_DROME Glutaminyl-peptide cyclotransferase (Gene Name=isoQC)

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