Structure of PDB 4fak Chain A Binding Site BS02

Receptor Information

>4fak Chain A (length=163) Species: 1280 (Staphylococcus aureus)

AAEFMKITILAVGKLKEKYWKQAIAEYEKRLGPYTKIDIIEVPDEKAPEN
MSDKEIEQVKEKEGQRILAKIKPQSTVITLEIQGKMLSSEGLAQELNQRM
TQGQSDFVFVIGGSNGLHKDVLQRSNYALSFSKMTFPHQMMRVVLIEQVY
RAFKIMRGEAYHK

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 4fak Chain A Residue 203

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4fak Characterization of the Staphylococcus aureus rRNA Methyltransferase Encoded by orfX, the Gene Containing the Staphylococcal Chromosome Cassette mec (SCCmec) Insertion Site.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): S110 P133 H134
• Binding residue (residue number reindexed from 1): S114 P137 H138
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.1.1.177: 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase.

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity
• GO:0070038 rRNA (pseudouridine-N3-)-methyltransferase activity

Biological Process

• GO:0006364 rRNA processing
• GO:0031167 rRNA methylation
• GO:0032259 methylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4fak, PDBe:4fak, PDBj:4fak
• PDBsum: 4fak
• PubMed: 23150671
• UniProt: P0C1V0|RLMH_STAAU Ribosomal RNA large subunit methyltransferase H (Gene Name=rlmH)