Structure of PDB 4f4u Chain A Binding Site BS02

Receptor Information

>4f4u Chain A (length=266) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFGYWRKWQAQDLA
TPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVV
VITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSG
KGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVD
RELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFR
FHFQGPCGTTLPEALA

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4f4u Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4f4u The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)
Resolution	2.0 Å
Binding residue (original residue number in PDB)	C166 C169 C207 C212
Binding residue (residue number reindexed from 1)	C130 C133 C171 C176
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	P68 T69 F70 N141 D143 H158
Catalytic site (residue number reindexed from 1)	P36 T37 F38 N105 D107 H122
Enzyme Commision number	2.3.1.-

Gene Ontology

	Molecular Function
GO:0036054	protein-malonyllysine demalonylase activity
GO:0036055	protein-succinyllysine desuccinylase activity
GO:0070403	NAD+ binding

View graph for
Molecular Function

External links

PDB	RCSB:4f4u, PDBe:4f4u, PDBj:4f4u
PDBsum	4f4u
PubMed	22767592
UniProt	Q9NXA8\|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

[Back to BioLiP]