Structure of PDB 4f2s Chain A Binding Site BS02

Receptor Information
>4f2s Chain A (length=578) Species: 235909 (Geobacillus kaustophilus HTA426) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFLRP
ETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLLAA
YLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEHLV
RKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVDTK
RLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPVLK
KTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVRPA
TKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESDWL
IFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSEDEVT
PNMRRQAKAVNYGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPGVKR
YMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTPIQG
SAADIIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMERLCRLV
PEVMEQAVTLRVPLKVDYHYGSTWYDAK
Ligand information
Receptor-Ligand Complex Structure
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PDB4f2s Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
Resolution1.651 Å
Binding residue
(original residue number in PDB)
N527 N529 S530 K582 S585 T586 T611 Q612 T613 R615 S617 S618 T619 E620 N622 Y710 G711 Y714 I716 S717 Y719 G720 N724 R771 F786 R789 M790 N793 Q797
Binding residue
(residue number reindexed from 1)
N229 N231 S232 K284 S287 T288 T313 Q314 T315 R317 S319 S320 T321 E322 N324 Y412 G413 Y416 I418 S419 Y421 G422 N426 R473 F488 R491 M492 N495 Q499
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function

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Biological Process
External links
PDB RCSB:4f2s, PDBe:4f2s, PDBj:4f2s
PDBsum4f2s
PubMed
UniProtQ5KWC1

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