Structure of PDB 4ew0 Chain A Binding Site BS02

Receptor Information
>4ew0 Chain A (length=143) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WTPPRSPFNLVQEILFHDPWKLLIATIFLNRTSGKMAIPVLWEFLEKYPS
AEVARAADWRDVSELLKPLGLYDLRAKTIIKFSDEYLTKQWRYPIELHGI
GKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLSLS
Ligand information
Receptor-Ligand Complex Structure
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PDB4ew0 Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation.
Resolution2.39 Å
Binding residue
(original residue number in PDB)		L421 Q423 L440 N441 R442 T443 S444 K446 G510 I511 G512 Y514 N534 K536
Binding residue
(residue number reindexed from 1)		L10 Q12 L29 N30 R31 T32 S33 K35 G99 I100 G101 Y103 N123 K125
Enzymatic activity
Enzyme Commision number 3.2.2.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4ew0, PDBe:4ew0, PDBj:4ew0
PDBsum4ew0
PubMed22740654
UniProtQ9Z2D7|MBD4_MOUSE Methyl-CpG-binding domain protein 4 (Gene Name=Mbd4)

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