Structure of PDB 4ecs Chain A Binding Site BS02

Receptor Information
>4ecs Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRA
AIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPI
RKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMC
RGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERL
TKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTV
IKNCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB4ecs Watching DNA polymerase eta make a phosphodiester bond
Resolution1.951 Å
Binding residue
(original residue number in PDB)		F18 R61 S113 D115 E116 K224 S257 G259 K261 L262 R377 L381 R382 C384
Binding residue
(residue number reindexed from 1)		F21 R64 S116 D118 E119 K222 S255 G257 K259 L260 R375 L379 R380 C382
Enzymatic activity
Catalytic site (original residue number in PDB) D13 M14 Y52 R55 R61 S113 D115 E116 K231
Catalytic site (residue number reindexed from 1) D16 M17 Y55 R58 R64 S116 D118 E119 K229
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4ecs, PDBe:4ecs, PDBj:4ecs
PDBsum4ecs
PubMed22785315
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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