Structure of PDB 4dur Chain A Binding Site BS02
Receptor Information
>4dur Chain A (length=756) Species:
9606
(Homo sapiens) [
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LDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQ
QCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNG
ITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEK
RYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIP
SKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGP
TYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDE
NYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDPTAPPELTPVVQDCYHGD
GQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDA
DKGPWCFTTDPSVRWEYCNLKKCSGSEEDCMFGNGKGYRGKRATTVTGTP
CQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKL
YDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTR
FGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQE
IEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFI
TGWGETFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTD
SCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIE
GVMRNN
Ligand information
Ligand ID
CL
InChI
InChI=1S/ClH/h1H/p-1
InChIKey
VEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
Software
SMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0
[Cl-]
Formula
Cl
Name
CHLORIDE ION
ChEMBL
DrugBank
DB14547
ZINC
PDB chain
4dur Chain A Residue 803 [
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Receptor-Ligand Complex Structure
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PDB
4dur
The X-ray crystal structure of full-length human plasminogen
Resolution
2.45 Å
Binding residue
(original residue number in PDB)
R234 K708
Binding residue
(residue number reindexed from 1)
R232 K673
Annotation score
3
Enzymatic activity
Catalytic site (original residue number in PDB)
H603 D646 Q738 G739 D740 S741 G742
Catalytic site (residue number reindexed from 1)
H571 D614 Q703 G704 D705 S706 G707
Enzyme Commision number
3.4.21.7
: plasmin.
Gene Ontology
Molecular Function
GO:0002020
protease binding
GO:0004175
endopeptidase activity
GO:0004252
serine-type endopeptidase activity
GO:0005102
signaling receptor binding
GO:0005515
protein binding
GO:0008236
serine-type peptidase activity
GO:0019899
enzyme binding
GO:0019900
kinase binding
GO:0019904
protein domain specific binding
GO:0034185
apolipoprotein binding
GO:0051087
protein-folding chaperone binding
GO:1990405
protein antigen binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
GO:0008285
negative regulation of cell population proliferation
GO:0010812
negative regulation of cell-substrate adhesion
GO:0016485
protein processing
GO:0022617
extracellular matrix disassembly
GO:0042246
tissue regeneration
GO:0042730
fibrinolysis
GO:0043536
positive regulation of blood vessel endothelial cell migration
GO:0045445
myoblast differentiation
GO:0046716
muscle cell cellular homeostasis
GO:0048771
tissue remodeling
GO:0051702
biological process involved in interaction with symbiont
GO:0051918
negative regulation of fibrinolysis
GO:0051919
positive regulation of fibrinolysis
GO:0060707
trophoblast giant cell differentiation
GO:0060716
labyrinthine layer blood vessel development
GO:0071674
mononuclear cell migration
GO:0099183
trans-synaptic signaling by BDNF, modulating synaptic transmission
GO:2000048
negative regulation of cell-cell adhesion mediated by cadherin
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
GO:0005886
plasma membrane
GO:0009897
external side of plasma membrane
GO:0009986
cell surface
GO:0031093
platelet alpha granule lumen
GO:0062023
collagen-containing extracellular matrix
GO:0070062
extracellular exosome
GO:0072562
blood microparticle
GO:0098685
Schaffer collateral - CA1 synapse
GO:0098978
glutamatergic synapse
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:4dur
,
PDBe:4dur
,
PDBj:4dur
PDBsum
4dur
PubMed
22832192
UniProt
P00747
|PLMN_HUMAN Plasminogen (Gene Name=PLG)
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