Structure of PDB 4dsk Chain A Binding Site BS02

Receptor Information
>4dsk Chain A (length=575) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFLR
PETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLLA
AYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEHL
VRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVDT
KRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPVL
KGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVRPDTKK
VHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESDWLIFA
ADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSEDEVTPNM
RRQAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPGVKRYME
NIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTPIQGSAA
DIIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMERLCRLVPEV
MEQAVTLRVPLKVDYHYGSTWYDAK
Ligand information
Receptor-Ligand Complex Structure
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PDB4dsk Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase
Resolution2.18 Å
Binding residue
(original residue number in PDB)		N527 S530 K582 S585 T586 T611 Q612 T613 S617 S618 T619 N622 A707 G711 Y714 G720 L721 N724 R771 F786 R789 M790 N793 Q797
Binding residue
(residue number reindexed from 1)		N230 S233 K281 S284 T285 T310 Q311 T312 S316 S317 T318 N321 A406 G410 Y413 G419 L420 N423 R470 F485 R488 M489 N492 Q496
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004518 nuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006974 DNA damage response
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4dsk, PDBe:4dsk, PDBj:4dsk
PDBsum4dsk
PubMed
UniProtE1C9K5

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