Structure of PDB 4da4 Chain A Binding Site BS02

Receptor Information
>4da4 Chain A (length=834) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLAR
VTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYI
HSKVKVIYKAPSENWAMEGGEDGKTYFFQLWYNQEYARFESPPKTQPTED
NKHKFCLSCIRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGD
SVYLPPEAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYSDYIKGSNLDA
PEPYRIGRIKEIHCGKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHTD
INMLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEA
YNSKTKNFEDPPNHARSPGNIKLPKLRTLDVFSGCGGLSEGFHQAGISET
LWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQ
KGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFF
LLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRA
IILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFR
TITVRDTMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHI
CKDMSPLVAARMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVK
NGYSSTGALRGVCSCAEGKACDPESRQFSTLIPWCLPHTGNRHNHWAGLY
GRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYR
FFGNILDRHRQVGNAVPPPLAKAIGLEIKLCLLS
Ligand information
Receptor-Ligand Complex Structure
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PDB4da4 Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		S981 Y983 K985 P1227 P1228 C1229 Q1230 S1233 M1235 N1236 F1238 Y1243 E1269 V1271 R1313 R1314 R1315 N1510 T1530 G1536 K1537 N1580
Binding residue
(residue number reindexed from 1)		S240 Y242 K244 P461 P462 C463 Q464 S467 M469 N470 F472 Y477 E503 V505 R547 R548 R549 N744 T764 G770 K771 N814
Enzymatic activity
Catalytic site (original residue number in PDB) C1229 E1269 R1313 R1315
Catalytic site (residue number reindexed from 1) C463 E503 R547 R549
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4da4, PDBe:4da4, PDBj:4da4
PDBsum4da4
PubMed22323818
UniProtP13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)

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