Structure of PDB 4cqo Chain A Binding Site BS02

Receptor Information
>4cqo Chain A (length=510) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKT
DDLITRFFRLCTEMCVEISYRAQAEPTMIRAKCYHNLDAFVRLIALLVKH
SGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLL
ELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIA
RMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVTKPMQILYKGTLRVLLV
LLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLK
VDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQ
VSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIF
QNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQ
EQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEK
LFQSVAQCCM
Ligand information
Receptor-Ligand Complex Structure
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PDB4cqo Structural Basis for the Nanos-Mediated Recruitment of the Ccr4-not Complex and Translational Repression
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R1992 L1999 E2040 H2044
Binding residue
(residue number reindexed from 1)		R143 L150 E191 H195
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0017148 negative regulation of translation
Cellular Component
GO:0030015 CCR4-NOT core complex

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Biological Process
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Cellular Component
External links
PDB RCSB:4cqo, PDBe:4cqo, PDBj:4cqo
PDBsum4cqo
PubMed24736845
UniProtA5YKK6|CNOT1_HUMAN CCR4-NOT transcription complex subunit 1 (Gene Name=CNOT1)

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