Structure of PDB 4clu Chain A Binding Site BS02

Receptor Information

>4clu Chain A (length=460) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISG
FTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDA
LLALWRVERKQLKNIITVVIKCSLEIHGLFETLDIRVKIGLAAGHISMLV
FGDETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIES
VPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLK
PDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMFEDQDK
AEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVP
DELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTV
IGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADS
GPLYQYWGRT

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

4clu Chain A Residue 1475 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4clu Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	D47 D99
Binding residue (residue number reindexed from 1)	D47 D99
Annotation score	1

Enzymatic activity

Enzyme Commision number

4.6.1.1: adenylate cyclase.

Gene Ontology

	Biological Process
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

View graph for
Biological Process

External links

PDB	RCSB:4clu, PDBe:4clu, PDBj:4clu
PDBsum	4clu
PubMed	24567411
UniProt	Q96PN6\|ADCYA_HUMAN Adenylate cyclase type 10 (Gene Name=ADCY10)

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