Structure of PDB 4cdg Chain A Binding Site BS02

Receptor Information
>4cdg Chain A (length=625) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFIL
MPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLT
GDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKL
LARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQ
KDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPY
DSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQD
GCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISH
CLLFYTYHDVTRLKRTRETHFNNLYSMVHYCENITECRRIQLLAYFGENG
FNPDFCKKHPDVSCDNCCKTKDYKTRDVTDDVKSIVRFVQEHRFTMNMLV
DIFLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYINAND
QAIAYVMLGNKAQTVLNGNLKVDFMETENSSSVKKQKALVAKVSQREEMV
KKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDG
VTEDKLEKYGAEVISVLQKYSEWTS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4cdg Chain A Residue 1643 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4cdg Crystal Structure of the Bloom'S Syndrome Helicase Indicates a Role for the Hrdc Domain in Conformational Changes.
Resolution2.794 Å
Binding residue
(original residue number in PDB)		C1036 C1055 C1063 C1066
Binding residue
(residue number reindexed from 1)		C387 C406 C414 C417
Annotation score1
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0044237 cellular metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4cdg, PDBe:4cdg, PDBj:4cdg
PDBsum4cdg
PubMed25901030
UniProtP54132|BLM_HUMAN RecQ-like DNA helicase BLM (Gene Name=BLM)

[Back to BioLiP]