Structure of PDB 4ccn Chain A Binding Site BS02

Receptor Information

>4ccn Chain A (length=458) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRRLWEREAVLVR
RQDHTYYQGLFSTADLDSMLRNEEVQFGQHLDAARYINGRRETLNPPGRA
LPAAAWSLYQAGCSLRLCSPQAFSTTVWQFLAVLQEQFGSMAGSNVYLTP
PNSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRAPTEELALTSSPNFSQDD
LGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDF
LEAILPLAVQAAMEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKV
RVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVYGLPIRWE
GEPVNVGAQLTTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEEP
KCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLSLATTLYDKGLL
LTKMPLAL

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

4ccn Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4ccn Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Resolution	2.23 Å
Binding residue (original residue number in PDB)	H340 D342 H405
Binding residue (residue number reindexed from 1)	H159 D161 H224
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
1.14.11.79: protein-L-histidine (3S)-3-hydroxylase.

External links

PDB	RCSB:4ccn, PDBe:4ccn, PDBj:4ccn
PDBsum	4ccn
PubMed	24814345
UniProt	Q9H6W3\|RIOX1_HUMAN Ribosomal oxygenase 1 (Gene Name=RIOX1)

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