Structure of PDB 4bas Chain A Binding Site BS02

Receptor Information

>4bas Chain A (length=172) Species: 185431 (Trypanosoma brucei brucei TREU927)

TKLQVVMCGLDNSGKTTIINQVKPAQHITATVGYNVETFEKGRVAFTVFD
MGGAKKFRGLWETYYDNIDAVIFVVDSSDHLRLCVVKSEIQAMLKHEDIR
RELPGGGRVPFLFFANKMDAAGAKTAAELVEILDLTTLMGDHPFVIFASN
GLKGTGVHEGFSWLQETASRQS

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4bas Chain A Residue 1183

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4bas Crystal Structure of the Small Gtpase Arl6/Bbs3 from Trypanosomabrucei.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): T21 T40
• Binding residue (residue number reindexed from 1): T16 T31
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): A63
• Catalytic site (residue number reindexed from 1): A54
• Enzyme Commision number: 3.6.5.2: small monomeric GTPase.

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006886 intracellular protein transport
• GO:0016192 vesicle-mediated transport
• GO:0060271 cilium assembly
• GO:0061512 protein localization to cilium

Cellular Component

• GO:0005737 cytoplasm
• GO:0005930 axoneme

External links

• PDB: RCSB:4bas, PDBe:4bas, PDBj:4bas
• PDBsum: 4bas
• PubMed: 23184293
• UniProt: C9ZVV9