Structure of PDB 4azc Chain A Binding Site BS02

Receptor Information

>4azc Chain A (length=416) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GSHMEKLAKNKVISIDAGRKYFTLNQLKRIVDKASELGYSDVHLLLGNDG
LRFLLDDMTITANGKTYASDDVKKAIIEGTKAYYDDPNGTALTQAEVTEL
IEYAKSKDIGLIPAINSPGHMDAMLVAMEKLGIKNPQAHFDKVSKTTMDL
KNEEAMNFVKALIGKYMDFFAGKTKIFNFGTDEYANDATSAQGWYYLKWY
QLYGKFAEYANTLAAMAKERGLQPMAFNDGFYYEDKDDVQFDKDVLISYW
SKGWWGYNLASPQYLASKGYKFLNTNGDWYYILGQKPEDGGGFLKKAIEN
TGKTPFNQLASTKYPEVDLPTVGSMLSIWADRPSAEYKEEEIFELMTAFA
DHNKDYFRANYNALREELAKIPTGYSKESLEALDAAKTALNYNLNRNKQA
ELDTLVANLKAALQGK

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

4azc Chain A Residue 2044 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4azc Inhibition of the Family 20 Glycoside Hydrolase Catalytic Modules in the Streptococcus Pneumoniae Exo-Beta-D-N-Acetylglucosaminidase, Strh.
Resolution	2.09 Å
Binding residue (original residue number in PDB)	K764 V765
Binding residue (residue number reindexed from 1)	K142 V143
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.2.1.52: beta-N-acetylhexosaminidase.

Gene Ontology

	Molecular Function
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds

	Biological Process
GO:0005975	carbohydrate metabolic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:4azc, PDBe:4azc, PDBj:4azc
PDBsum	4azc
PubMed	24132305
UniProt	P49610\|STRH_STRPN Beta-N-acetylhexosaminidase (Gene Name=strH)

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