Structure of PDB 4awb Chain A Binding Site BS02

Receptor Information
>4awb Chain A (length=261) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIA
YSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVK
GIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYK
HKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKR
STYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTQTSHVMQYGNKTI
STMKVMQFQGM
Ligand information
Receptor-Ligand Complex Structure
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PDB4awb Mechanistic and Structural Studies on Legumain Explain its Zymogenicity, Distinct Activation Pathways, and Regulation
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R44 D147 H148 C189 R213 S216 D231
Binding residue
(residue number reindexed from 1)		R19 D122 H123 C164 R188 S191 D206
Enzymatic activity
Enzyme Commision number 3.4.22.34: legumain.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4awb, PDBe:4awb, PDBj:4awb
PDBsum4awb
PubMed23776206
UniProtQ99538|LGMN_HUMAN Legumain (Gene Name=LGMN)

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