Structure of PDB 4au2 Chain A Binding Site BS02

Receptor Information

>4au2 Chain A (length=367) Species: 9615 (Canis lupus familiaris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MLSPKAATLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLG
GKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNVTWKLGSRLYGPSS
VSFAEDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVT
KDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHR
TGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQ
LKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSR
MSGKKDLYLASVFHATAFEWDTEGNPFDLRSPKLFYADHPFIFLVRDTQS
GSLLFIGRLVRPKGDKM

Ligand information

>4au2 Chain F (length=14) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

PPGPPGPRGPPGPP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4au2 Molecular Basis for the Action of the Collagen-Specific Chaperone Hsp47/Serpinh1 and its Structure-Specific Client Recognition.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	R228 L381 Y383
Binding residue (residue number reindexed from 1)	R189 L334 Y336

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005518	collagen binding

	Cellular Component
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4au2, PDBe:4au2, PDBj:4au2
PDBsum	4au2
PubMed	22847422
UniProt	C7C419

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