Structure of PDB 4acb Chain A Binding Site BS02

Receptor Information

>4acb Chain A (length=452) Species: 39152 (Methanococcus maripaludis)

HMDFKNINLGIFGHIDHGKTTLSKVLTEITIDIGFSAFKLENYRITLVDA
PGHADLIRAVVSAADIIDLALIVVDAKEGPKTQTGEHMLILDHFNIPIIV
VITKSDNAGTEEIKRTEMIMKSILQSTHNLKNSSIIPISAKTGFGVDELK
NLIITTLNNAEIIRNTESYFKMPLDHAFPIKGAGTVVTGTINKGIVKVGD
ELKVLPINMSTKVRSIQYFKESVMEAKAGDRVGMAIQGVDAKQIYRGCIL
TSKDTKLQTVDKIVAKIKISDIFKYNLTPKMKVHLNVGMLIVPAVAVPFK
KVTFGKTEENIILNEVISGNECYCAFELEEKVLAEVGDRVLITRLDLPPT
TLRICGHGLIEEFKPIKDLNIKKEVLREGKVKIDKGRTVIDGLAQSKVAA
EKLIGEEISIEGKDIVGKIKGTFGTKGLLTAEFSGNVENRDKVILNRLRR
WG

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4acb Chain A Residue 1470

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4acb Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors.
• Resolution: 3.34 Å
• Binding residue (original residue number in PDB): T19 T46
• Binding residue (residue number reindexed from 1): T20 T30
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D15 K18 T19 T46 H69
• Catalytic site (residue number reindexed from 1): D16 K19 T20 T30 H53

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0001514 selenocysteine incorporation
• GO:0006414 translational elongation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4acb, PDBe:4acb, PDBj:4acb
• PDBsum: 4acb
• PubMed: 15616587
• UniProt: Q8J307