Structure of PDB 4a35 Chain A Binding Site BS02

Receptor Information
>4a35 Chain A (length=441) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMVRGRISRLSVRDVRFPTSLGGHGADAMHTDPDYSAAYVVIETDAEDGI
KGCGITFTLGKGTEVVVCAVNALAHHVLNKDLKDIVGDFRGFYRQLTSDG
QLRWIGPEKGVVHLATAAVLNAVWDLWAKQEGKPVWKLLVDMDPRMLVSC
IDFRYITDVLTEEDALEILQKGQIGKKEREKQMLAQGYPAYTTSCAWLGY
SDDTLKQLCAQALKDGWTRFKVKVGADLQDDMRRCQIIRDMIGPEKTLMM
DANQRWDVPEAVEWMSKLAKFKPLWIEEPTSPDDILGHATISKALVPLGI
GIATGEQCHNRVIFKQLLQAKALQFLQIDSCRLGSVNENLSVLLMAKKFE
IPVCPHAGGVGLCELVQHLIIFDYISVSASLENRVCEYVDHLHEHFKYPV
MIQRASYMPPKDPGYSTEMKEESVKKHQYPDGEVWKKLLPA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4a35 Chain A Residue 1446 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4a35 Enzymatic and structural characterization of rTS gamma provides insights into the function of rTS beta.
Resolution1.74 Å
Binding residue
(original residue number in PDB)		Y191 Y377
Binding residue
(residue number reindexed from 1)		Y188 Y374
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K224 K226 D254 N256 E280 E309 D332 H359 S383 E390
Catalytic site (residue number reindexed from 1) K221 K223 D251 N253 E277 E306 D329 H356 S380 E387
Enzyme Commision number 4.2.1.68: L-fuconate dehydratase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016829 lyase activity
GO:0016836 hydro-lyase activity
GO:0016853 isomerase activity
GO:0046872 metal ion binding
GO:0050023 L-fuconate dehydratase activity
Biological Process
GO:0009063 amino acid catabolic process
GO:0016052 carbohydrate catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4a35, PDBe:4a35, PDBj:4a35
PDBsum4a35
PubMed24697329
UniProtQ7L5Y1|ENOF1_HUMAN Mitochondrial enolase superfamily member 1 (Gene Name=ENOSF1)

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