Structure of PDB 3zyq Chain A Binding Site BS02

Receptor Information
>3zyq Chain A (length=216) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVND
KNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVR
NKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAE
RAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGI
EKEVRVCEPCYEQLNR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3zyq Chain A Residue 1223 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3zyq Crystal Structure of the Tandem Vhs and Fyve Domains of Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) at 1.48 A Resolution
Resolution1.48 Å
Binding residue
(original residue number in PDB)		C182 C185 C212 C215
Binding residue
(residue number reindexed from 1)		C177 C180 C207 C210
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0035091 phosphatidylinositol binding
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:3zyq, PDBe:3zyq, PDBj:3zyq
PDBsum3zyq
PubMed
UniProtO14964|HGS_HUMAN Hepatocyte growth factor-regulated tyrosine kinase substrate (Gene Name=HGS)

[Back to BioLiP]