Structure of PDB 3zwf Chain A Binding Site BS02

Receptor Information

>3zwf Chain A (length=259) Species: 9606 (Homo sapiens)

MDVTFLGTGAAYPSPTRGASAVVLRCEGECWLFDCGEGTQTQLMKSQLKA
GRITKIFITHLHGDHFFGLPGLLCTISLQSQPIEIYGPVGLRDFIWRTME
LSHTELVFHYVVHELVPTADQCPAQGRTILLDSEENSYLLFDDEQFVVKA
FRLFHRIPSFGFSVVEKKVGRKICILGDCSGVVGDGGVKLCFEADLLIHE
ATLDDAQMDKAKEHGHSTPQMAATFAKLCRAKRLVLTHFSQRYQEVTLAE
DFMVISIPI

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 3zwf Chain A Residue 1364

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3zwf Crystal Structure of Human Trnase Z, Short Form (Elac1).
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): H62 H64 H182 D253
• Binding residue (residue number reindexed from 1): H60 H62 H155 D178
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.26.11: ribonuclease Z.

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity
• GO:0004549 tRNA-specific ribonuclease activity
• GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters
• GO:0042781 3'-tRNA processing endoribonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0008033 tRNA processing
• GO:0042780 tRNA 3'-end processing
• GO:0072344 rescue of stalled ribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:3zwf, PDBe:3zwf, PDBj:3zwf
• PDBsum: 3zwf
• UniProt: Q9H777|RNZ1_HUMAN Zinc phosphodiesterase ELAC protein 1 (Gene Name=ELAC1)