Structure of PDB 3wxm Chain A Binding Site BS02

Receptor Information
>3wxm Chain A (length=432) Species: 272557 (Aeropyrum pernix K1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPHMNLVVIGHVDHGKSTLVGHLLYRLGYIEEKKLKELEEQAKSRGKESF
KFAWILDKMKEERERGITIDLTFMKFETKKYVFTIIDAPGHRDFVKNMIT
GASQADAAILVVSARKGEFEAGMSTEGQTREHLLLARTMGIEQIIVAVNK
MDAPDVNYDQKRYEFVVSVLKKFMKGLGYQVDKIPFIPVSAWKGDNLIER
SPNMPWYNGPTLVEALDQLQPPAKPVDKPLRIPVQNVYSIPGAGTVPVGR
VETGVLRVGDKVVFMPPGVVGEVRSIEMHYQQLQQAEPGDNIGFAVRGVS
KSDIKRGDVAGHLDKPPTVAEEFEARIFVIWHPSAITVGYTPVIHVHTAS
VSSRIIEIKAKLDPKTGQVVEQNPQFLKAGDAAIVRFKPVKPLVVEKFSE
IPQLGRFAMRDMNRTVGIGIVTDVKPAKVDIK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3wxm Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3wxm Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1 alpha complex
Resolution2.3 Å
Binding residue
(original residue number in PDB)		S20 T71
Binding residue
(residue number reindexed from 1)		S17 T68
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D16 K19 S20 T71 H94
Catalytic site (residue number reindexed from 1) D13 K16 S17 T68 H91
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wxm, PDBe:3wxm, PDBj:3wxm
PDBsum3wxm
PubMed20876129
UniProtQ9YAV0|EF1A_AERPE Elongation factor 1-alpha (Gene Name=tuf)

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