Structure of PDB 3wvw Chain A Binding Site BS02

Receptor Information
>3wvw Chain A (length=173) Species: 9796 (Equus caballus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSQIRQNYSTEVEAAVNRLVNLYLRASYTYLSLGFYFDRDDVALEGVCHF
FRELAEEKREGAERLLKMQNQRGGRALFQDLQKPSQDEWGTTLDAMKAAI
VLEKSLNQALLDLHALGSAQADPHLCDFLESHFLDEEVKLIKKMGDHLTN
IQRLVGSQAGLGEYLFERLTLKH
Ligand information
Ligand IDRU1
InChIInChI=1S/2CO.Ru/c2*1-2;/q2*+1;+2
InChIKeyHLYOBVRGNSSECA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C(#[O+])[Ru+2]C#[O+]
CACTVS 3.385[O+]#C[Ru++]C#[O+]
ACDLabs 12.01[O+]#C[Ru+2]C#[O+]
FormulaC2 O2 Ru
Namebis(oxidaniumylidynemethyl)ruthenium(2+)
ChEMBL
DrugBank
ZINC
PDB chain3wvw Chain A Residue 215 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3wvw Intracellular CO release from composite of ferritin and ruthenium carbonyl complexes.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		D38 E45 C48
Binding residue
(residue number reindexed from 1)		D38 E45 C48
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0046872 metal ion binding
Biological Process
GO:0006826 iron ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0006880 intracellular sequestering of iron ion
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005776 autophagosome
GO:0031410 cytoplasmic vesicle
GO:0044754 autolysosome
GO:0070288 ferritin complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wvw, PDBe:3wvw, PDBj:3wvw
PDBsum3wvw
PubMed25352251
UniProtP02791|FRIL_HORSE Ferritin light chain (Gene Name=FTL)

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