Structure of PDB 3w4u Chain A Binding Site BS02

Receptor Information
>3w4u Chain A (length=141) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLTKTERTIIVSMWAKISTQADTIGTETLERLFLSHPQTKTYFPHFDLHP
GSAQLRAHGSKVVAAVGDAVKSIDDIGGALSKLSELHAYILRVDPVNFKL
LSHCLLVTLAARFPADFTAEAHAAWDKFLSVVSSVLTEKYR
Ligand information
Ligand IDCMO
InChIInChI=1S/CO/c1-2
InChIKeyUGFAIRIUMAVXCW-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[O+]#[C-]
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[C-]#[O+]
FormulaC O
NameCARBON MONOXIDE
ChEMBLCHEMBL1231840
DrugBankDB11588
ZINC
PDB chain3w4u Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3w4u Structure of fully liganded Hb zeta 2 beta 2(s) trapped in a tense conformation
Resolution1.95 Å
Binding residue
(original residue number in PDB)		H58 V62
Binding residue
(residue number reindexed from 1)		H58 V62
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0005344 oxygen carrier activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0031720 haptoglobin binding
GO:0043177 organic acid binding
GO:0046872 metal ion binding
Biological Process
GO:0015670 carbon dioxide transport
GO:0015671 oxygen transport
GO:0042744 hydrogen peroxide catabolic process
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005833 hemoglobin complex
GO:0031838 haptoglobin-hemoglobin complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3w4u, PDBe:3w4u, PDBj:3w4u
PDBsum3w4u
PubMed24100324
UniProtP02008|HBAZ_HUMAN Hemoglobin subunit zeta (Gene Name=HBZ)

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