Structure of PDB 3vrr Chain A Binding Site BS02

Receptor Information

>3vrr Chain A (length=291) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EEARALGRAVRMLQRLEEQCVDVSPPSLRDLLPRTAQLLREVAHSRRAGG
PGGPGGSGDFLLIYLANLEAKSRQVAALLPPRELFRAGSRLRRQLAKLAI
IFSHMHAELHALFPGGKYCGHMYQLTKAPAHTFWRESCGARCVLPWAEFE
SLLGTCHPVEPGCTALALRTTIDLTCSGHVSIFEFDVFTRLFQPWPTLLK
NWQLLAVNHPGYMAFLTYDEVQERLQACRDKPGSYIFRLSCTRLGQWAIG
YVSSDGSILQTIPANKPLSQVLLEGQKDGFYLYPDGKTHNP

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

3vrr Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3vrr Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	D199 T201 S203 H205 E210
Binding residue (residue number reindexed from 1)	D173 T175 S177 H179 E184
Annotation score	4

Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

Gene Ontology

	Molecular Function
GO:0001784	phosphotyrosine residue binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0007166	cell surface receptor signaling pathway
GO:0023051	regulation of signaling

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Molecular Function

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Biological Process

External links

PDB	RCSB:3vrr, PDBe:3vrr, PDBj:3vrr
PDBsum	3vrr
PubMed	22888118
UniProt	Q9ULV8\|CBLC_HUMAN E3 ubiquitin-protein ligase CBL-C (Gene Name=CBLC)

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