Structure of PDB 3vaz Chain A Binding Site BS02

Receptor Information
>3vaz Chain A (length=334) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQ
GRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYT
DKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASC
TTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARA
AAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEK
QDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMS
VGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELS
Ligand information
Ligand IDDGY
InChIInChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/t2-/m1/s1
InChIKeyRBNPOMFGQQGHHO-UWTATZPHSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(O)CO
OpenEye OEToolkits 1.5.0C(C(C(=O)O)O)O
CACTVS 3.341OC[CH](O)C(O)=O
OpenEye OEToolkits 1.5.0C([C@H](C(=O)O)O)O
CACTVS 3.341OC[C@@H](O)C(O)=O
FormulaC3 H6 O4
Name(2R)-2,3-DIHYDROXYPROPANOIC ACID
ChEMBL
DrugBank
ZINCZINC000000895140
PDB chain3vaz Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3vaz Crystal structure of Staphylococcal GAPDH1 in a hexagonal space group
Resolution3.19 Å
Binding residue
(original residue number in PDB)		D165 D166 F167
Binding residue
(residue number reindexed from 1)		D164 D165 F166
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) C151 H178
Catalytic site (residue number reindexed from 1) C150 H177
Enzyme Commision number 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0030554 adenyl nucleotide binding
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3vaz, PDBe:3vaz, PDBj:3vaz
PDBsum3vaz
PubMed
UniProtQ6GIL8|G3P1_STAAR Glyceraldehyde-3-phosphate dehydrogenase 1 (Gene Name=gapA1)

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