Structure of PDB 3v11 Chain A Binding Site BS02

Receptor Information
>3v11 Chain A (length=404) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNI
GVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLS
GAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSK
EEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPY
RDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVL
PGLRVVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNL
LGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSV
GSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWG
LVEI
Ligand information
>3v11 Chain D (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgu
cgguucaaauccggcccccgcaacca
<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>......<
<<<.......>>>>.>>>>>>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3v11 Structure of the ternary initiation complex aIF2-GDPNP-methionylated initiator tRNA.
Resolution5.0 Å
Binding residue
(original residue number in PDB)		S35 H37 S38 E39 F221 V223 P226 S278 R280 A296
Binding residue
(residue number reindexed from 1)		S29 H31 S32 E33 F215 V217 P220 S267 R269 A285
Binding affinityPDBbind-CN: Kd=1nM
Enzymatic activity
Catalytic site (original residue number in PDB) D19 K22 T23 T46 H97
Catalytic site (residue number reindexed from 1) D13 K16 T17 T40 H91
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation

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Molecular Function
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Biological Process
External links
PDB RCSB:3v11, PDBe:3v11, PDBj:3v11
PDBsum3v11
PubMed22447243
UniProtQ980A5|IF2G_SACS2 Translation initiation factor 2 subunit gamma (Gene Name=eif2g)

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