Structure of PDB 3uq2 Chain A Binding Site BS02

Receptor Information
>3uq2 Chain A (length=318) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSI
PGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMW
YQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKA
AQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLR
QEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFT
GSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGAKVGPGRVLPTPTEK
DVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB3uq2 The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda
Resolution2.25 Å
Binding residue
(original residue number in PDB)		W342 G343 A344 G345 K347 T348 D427 D429 D490 Y505 F506 G508 A510 N513
Binding residue
(residue number reindexed from 1)		W90 G91 A92 G93 K95 T96 D175 D177 D233 Y248 F249 G251 A253 N256
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D175 D177 D233
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3uq2, PDBe:3uq2, PDBj:3uq2
PDBsum3uq2
PubMed22584622
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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