Structure of PDB 3uq0 Chain A Binding Site BS02

Receptor Information
>3uq0 Chain A (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEAC
SIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQ
MWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQ
KAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDS
LRQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLY
FTGSAHFNRSMRALAKTKGMSLSEHALSTAVVGPGRVLPTPTEKDVFRLL
GLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB3uq0 The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda
Resolution2.14 Å
Binding residue
(original residue number in PDB)		W342 G343 A344 G345 K347 T348 K472 Y505 A510 N513
Binding residue
(residue number reindexed from 1)		W92 G93 A94 G95 K97 T98 K217 Y250 A255 N258
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D177 D179 D235
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3uq0, PDBe:3uq0, PDBj:3uq0
PDBsum3uq0
PubMed22584622
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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