Structure of PDB 3u6e Chain A Binding Site BS02
Receptor Information
>3u6e Chain A (length=252) Species:
1422
(Geobacillus stearothermophilus) [
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PQLPEVETIRRTLLPLIVGKTIEDVRIFWPNIIRHPRDSEAFAARMIGQT
VRGLERRGKFLKFLLDRDALISHLRMEGRYAVASALEPLEPHTHVVFCFT
DGSELRYRDVRKFGTMHVYAKEEADRRPPLAELGPEPLSPAFSPAVLAER
AVKTKRSVKALLLDCTVVAGFGNIYVDESLFRAGILPGRPAASLSSKEIE
RLHEEMVATIGEAVMHLYVYGRQGNPCKRCGTPIEKTVVAGRGTHYCPRC
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Ligand information
>3u6e Chain C (length=9) [
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ctggatcta
Receptor-Ligand Complex Structure
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PDB
3u6e
Sequence-dependent structural variation in DNA undergoing intrahelical inspection by the DNA glycosylase MutM.
Resolution
1.7 Å
Binding residue
(original residue number in PDB)
K60 H74 R76 R112 F114 P130 L134 C166 T167 N174 R264 G265
Binding residue
(residue number reindexed from 1)
K59 H73 R75 R111 F113 P129 L133 C165 T166 N173 R242 G243
Enzymatic activity
Catalytic site (original residue number in PDB)
P2 Q3
Catalytic site (residue number reindexed from 1)
P1 Q2
Enzyme Commision number
3.2.2.23
: DNA-formamidopyrimidine glycosylase.
4.2.99.18
: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676
nucleic acid binding
GO:0003677
DNA binding
GO:0003684
damaged DNA binding
GO:0003906
DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270
zinc ion binding
GO:0008534
oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0016787
hydrolase activity
GO:0016798
hydrolase activity, acting on glycosyl bonds
GO:0016799
hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829
lyase activity
GO:0019104
DNA N-glycosylase activity
GO:0034039
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0046872
metal ion binding
GO:0140078
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281
DNA repair
GO:0006284
base-excision repair
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Molecular Function
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Biological Process
External links
PDB
RCSB:3u6e
,
PDBe:3u6e
,
PDBj:3u6e
PDBsum
3u6e
PubMed
22465958
UniProt
P84131
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