Structure of PDB 3twy Chain A Binding Site BS02

Receptor Information
>3twy Chain A (length=137) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPK
NESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDF
MGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPE
Ligand information
Ligand IDPB
InChIInChI=1S/Pb/q+2
InChIKeyRVPVRDXYQKGNMQ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.370[Pb++]
valence
OpenEye OEToolkits 1.7.2[Pb+2]
FormulaPb
NameLEAD (II) ION
ChEMBL
DrugBank
ZINC
PDB chain3twy Chain A Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3twy Pb2+ as Modulator of Protein-Membrane Interactions.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		M186 D246 D248 D254
Binding residue
(residue number reindexed from 1)		M31 D91 D93 D99
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.13: protein kinase C.
External links
PDB RCSB:3twy, PDBe:3twy, PDBj:3twy
PDBsum3twy
PubMed21615172
UniProtP05696|KPCA_RAT Protein kinase C alpha type (Gene Name=Prkca)

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