Structure of PDB 3twx Chain A Binding Site BS02
Receptor Information
>3twx Chain A (length=158) Species:
9606
(Homo sapiens) [
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MGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGY
NRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN
VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGD
TDIQDLLR
Ligand information
>3twx Chain D (length=12) Species:
9606
(Homo sapiens) [
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QRESPDGQSFRS
Receptor-Ligand Complex Structure
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PDB
3twx
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
1.8 Å
Binding residue
(original residue number in PDB)
N537 V539 E573
Binding residue
(residue number reindexed from 1)
N51 V53 E87
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twx
,
PDBe:3twx
,
PDBj:3twx
PDBsum
3twx
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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