Structure of PDB 3tww Chain A Binding Site BS02
Receptor Information
>3tww Chain A (length=157) Species:
9606
(Homo sapiens) [
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GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN
RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV
ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDT
DIQDLLR
Ligand information
>3tww Chain D (length=11) Species:
9606
(Homo sapiens) [
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RQSPDGQSFRS
Receptor-Ligand Complex Structure
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PDB
3tww
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
N537 V539 E573
Binding residue
(residue number reindexed from 1)
N50 V52 E86
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3tww
,
PDBe:3tww
,
PDBj:3tww
PDBsum
3tww
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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