Structure of PDB 3tws Chain A Binding Site BS02
Receptor Information
>3tws Chain A (length=157) Species:
9606
(Homo sapiens) [
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SEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV
SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD
LWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDI
QDLLRGD
Ligand information
>3tws Chain H (length=11) Species:
9606
(Homo sapiens) [
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RGCADGQSFRS
Receptor-Ligand Complex Structure
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PDB
3tws
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
1.7 Å
Binding residue
(original residue number in PDB)
N537 V539 E543 E573
Binding residue
(residue number reindexed from 1)
N48 V50 E54 E84
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3tws
,
PDBe:3tws
,
PDBj:3tws
PDBsum
3tws
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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