Structure of PDB 3t6q Chain A Binding Site BS02

Receptor Information
>3t6q Chain A (length=601) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKCIEKEVNKTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSR
LINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPLIFMAETALSGPK
ALKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNHISSIKLPKGFPTEKL
KVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDIAGIEPGAFDSAVFQ
SLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMS
VESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLVGLSTLKK
LVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLREL
DLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELL
DLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLN
LQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHV
DLSHNRLTSSSIEALSHLKGIYLNLASNHISIILPSLLPILSQQRTINLR
QNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTLSC
S
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain3t6q Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3t6q Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		E269 H295
Binding residue
(residue number reindexed from 1)		E244 H270
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0002322 B cell proliferation involved in immune response
GO:0006954 inflammatory response
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045087 innate immune response
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005886 plasma membrane
GO:0072686 mitotic spindle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3t6q, PDBe:3t6q, PDBj:3t6q
PDBsum3t6q
PubMed21959264
UniProtQ62192|CD180_MOUSE CD180 antigen (Gene Name=Cd180)

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